AG 490 |
2-cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide |
(CAS 133550-30-8/134036-52-5) |
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Description: |
Protein tyrosine kinase (Ptk) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of Ptks. Tyrphostins are a class of antiproliferative compounds which act as Ptk blockers. Leukemic cells from patients in relapse have constitutively activated JAK2 Ptk. AG-490 is an inhibitor of JAK2 activity and selectively blocks leukemic cell growth in vitro and in vivo by inducing programmed cell death, with no deleterious effect on normal hematopoiesis. AG-490 almost completely blocks growth of all pre-B acute leukemia (ALL) cells at a concentration of 5 µM. |
Product No. |
KT00043 |
Product Name |
AG 490 |
Synonyms |
AG490;AG-490 |
Formal Name |
2-cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide |
CAS Number |
133550-30-8/134036-52-5 |
Molecular Formula |
C17H14N2O3 |
Formula Weight |
294.3 |
Formulation |
A crystalline solid |
Purity |
98%min |
Stability |
1 year |
Storage |
-20°C |
Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500. |
Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
Price & Availability |
In Stock. Price Negotiated. |
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