Tel:+86-21-51950625 51950635
Email us at sales@koutingchina.com
   
Products
MS-275 
N-[[4-[[(2-Aminophenyl)amino]carbonyl]phenyl]methyl]carbamic acid 3-pyridinylmethyl ester
(CAS 209783-80-2)
Description:
MS-275 strongly inhibits HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM, compared with HDACs 4, 6, 8, and 10.
MS-275 shows inhibitory to HDACs by 2'-amino group. MS-275 induces accumulation of p21WAF1/CIP1 and gelsolin in K562 cell. MS-275 could reduce S-phase cells and induce G1-phase cells in A2780 cell. MS-275 inhibits the proliferation of human tumor cell lines including A2780, Calu-3, HL-60, K562, St-4, HT-29, KB-3-1, Capan-1, 4-1St and HCT-15 with IC50 from 41.5 nM to 4.71 μM, which due to HAD-inhibition.MS-275 is not sensitive to other HDACs (4, 6, 8 and 10) with IC50 about/above 100 μM.MS-275 shows great inhibition to human leukemia and lymphoma cells, including U937, HL-60, K562, and Jurkat. MS-275 also decreases expression of cyclin D1 and the antiapoptotic proteins Mcl-1 and XIAP.
MS-275 exhibits great antitumor activity against human tumor xenografts except HCT-15 at 49 mg/kg.MS-275 demonstrates promising therapeutic potential in both solid and hematologic malignancies, as well as regulation of physiologic and aberrant gene expression.MS-275, combination with IL-2, has great antitumor activity to renal cell carcinoma xenograft model, which due to decreased T regulatory cells and increased splenocytes.
 

Product No. KT00588 
Product Name MS-275 
Synonyms Entinostat; SNDX-275
Formal Name N-[[4-[[(2-Aminophenyl)amino]carbonyl]phenyl]methyl]carbamic acid 3-pyridinylmethyl ester
CAS Number 209783-80-2
Molecular Formula C21H20N4O3
Formula Weight 376.41
Formulation A crystalline solid
Purity 98%min
Stability 2 years
Storage -20°C
Shipping USD45 for Europe and USA. No shipping charge once amount reach USD500
Quality Control HNMR,CNMR,LCMS,HPLC,IR,etc.
Price & Availability In Stock. Price Negotiated.
 
Not found? Pls contact with us for sourcing service.
Our contact email:sales@koutingchina.com
 
 
 
 
Related Products:

Order the product  * is required
Product:*
Your Name:*
Your Company:*
Add:
Tel:
Fax:
Web:
E-Mail:*
Your Demand :*

Products are for research use only. Not for human use. We do not sell to patients.
Copyrigh ©2009,China Kouting Group Limited All Rights Reserved. Supported by hxchem.net


products
Customer Service
Why Choose Us?
How to Order
How to Ship
How to Return
Frequently Asked Questions
Terms and Conditions
Email:sales@koutingchina.com
Skype: Notice