| ITF2357 |
| [4-[(hydroxyamino)carbonyl]phenyl]-[6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester-carbamic acid, monohydrochloride, monohydrate |
| (CAS 732302-99-7) |
 |
| Description： |
ITF 2357 inhibits class I and class II histone deacetylases (maize HDACs: HD2, HD-1B, and HD-1A with IC50s = 7.5-16 nM) and reduces the production of several pro-inflammatory cytokines including TNFα, IL-1α, and IL-1β (IC50s = 10-22 nM). ITF 2357 also has activity against cells expressing janus kinase 2 (JAK2)V617F (IC50s = 1-10 nM), a mutated form of the JAK2 enzyme that is implicated in the pathophysiology of many myeloproliferative diseases, including polycythaemia vera. |
| Product No. |
KT00460 |
| Product Name |
ITF2357 |
| Synonyms |
ITF-2357;ITF 2357 |
| Formal Name |
[4-[(hydroxyamino)carbonyl]phenyl]-[6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester-carbamic acid, monohydrochloride, monohydrate |
| CAS Number |
732302-99-7 |
| Molecular Formula |
C24H27N3O4•HCl [H2O] |
| Formula Weight |
476.0 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
|
|
