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AG013736 
N-​methyl-​2-​[[3-​[(1E)-​2-​(2-​pyridinyl)ethenyl]-​1H-​indazol-​6-​yl]thio]-​benzamide
(CAS 319460-85-0)
Description:

Axitinib is a tyrosine kinase inhibitor that blocks the activation of VEGFR-1, VEGFR-2, VEGFR-3, c-kit, and PDGFR-β (IC50 = 1.2, 0.25, 0.29, 1.7, and 1.6 nM, respectively). Through its effects on VEGFRs, it causes regression of fenestrated, VEGFR-rich capillaries in tumors and normal tissue of mice, which is reversed following removal of the inhibitor. Axitinib has shown promise as a therapeutic, in certain cancers and cancer models.

 

Product No. KT00044 
Product Name AG013736 
Synonyms Axitinib
Formal Name N-​methyl-​2-​[[3-​[(1E)-​2-​(2-​pyridinyl)ethenyl]-​1H-​indazol-​6-​yl]thio]-​benzamide
CAS Number 319460-85-0
Molecular Formula C22H18N4OS
Formula Weight 386.5
Formulation A crystalline solid
Purity 98%min
Stability 1 year
Storage -20°C
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