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ABT-737 
4-​[4-​[(4’-​chloro[1,​1’-​biphenyl]-​2-​yl)methyl]-​1-​piperazinyl]-​N-​[[4-​[[(1R)-​3-​(dimethylamino)-​1-​[(phenylthio)methyl]propyl]amino]-​3-​nitrophenyl]sulfonyl]-​benzamide
(CAS 852808-04-9)
Description:

The family of Bcl-2 proteins plays pivotal roles in either promoting or preventing apoptosis. Bcl-2 family members contain one or more of four characteristic Bcl-2 homology (BH) domains, which are crucial for function. For example, anti-apoptotic Bcl-2 family proteins prevent death signaling by heterodimerizing with pro-death proteins at their BH3 domains. ABT-737 is a potent, cell-permeable mimetic of BH3 domains that avidly binds Bcl-2, Bcl-XL, and Bcl-W (Ki < 1 nM for all three proteins). It blocks the interaction of these proteins with pro-death proteins, leading to apoptosis. ABT-737, alone, can induce regression of some tumors in some xenograft mouse models of cancer. It shows synergy with diverse therapeutics and radiation to trigger apoptosis in cancer cells and xenografts.

 

Product No. KT00027 
Product Name ABT-737 
Synonyms ABT737;ABT 737
Formal Name 4-​[4-​[(4’-​chloro[1,​1’-​biphenyl]-​2-​yl)methyl]-​1-​piperazinyl]-​N-​[[4-​[[(1R)-​3-​(dimethylamino)-​1-​[(phenylthio)methyl]propyl]amino]-​3-​nitrophenyl]sulfonyl]-​benzamide
CAS Number 852808-04-9
Molecular Formula C42H45ClN6O5S2
Formula Weight 813.4
Formulation A crystalline solid
Purity 98%min
Stability 1 year
Storage -20°C
Shipping USD45 for Europe and USA. No shipping charge once amount reach USD500.
Quality Control HNMR,CNMR,LCMS,HPLC,IR,etc.
Price & Availability In Stock. Price Negotiated.
 
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