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Bosutinib 
4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile
(CAS 380843-75-4)
Description:

Bosutinib (SKI-606) is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM, respectively.

The non-receptor tyrosine kinases c-Src and Abl have important roles in cell signaling and cancer. Bosutinib is best known as a potent dual inhibitor of c-Src and Abl (IC50 = 1.2 and 1.0 nM, respectively).Consistent with this action, bosutinib can be effective in regulating tumor growth and differentiation.Bosutinib is best known as a potent dual inhibitor of c-Src and Abl (IC50 = 1.2 and 1.0 nM, respectively).Consistent with this action, bosutinib can be effective in regulating tumor growth and differentiation.Bosutinib also inhibits, at nanomolar concentrations, other members of the Src family (e.g., Yes, Fgr, Lck, Fyn), as well as members of the TEC family, and certain other kinases.These actions extend the usefulness of this compound to cancers beyond those involving Src and Abl.

 

Product No. KT00833 
Product Name Bosutinib 
Synonyms SKI-606
Formal Name 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile
CAS Number 380843-75-4
Molecular Formula C26H29Cl2N5O3
Formula Weight 530.45
Formulation A crystalline solid
Purity 98%min
Stability 2 years
Storage -20°C
Shipping USD45 for Europe and USA. No shipping charge once amount reach USD500
Quality Control HNMR,CNMR,LCMS,HPLC,IR,etc.
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