| ABT263 |
| 4-[4-[[2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-benzamide |
| (CAS 923564-51-6) |
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| Description： |
The family of Bcl-2 proteins plays pivotal roles in either promoting or preventing apoptosis. Bcl-2 family members contain one or more of four characteristic Bcl-2 homology (BH) domains, which are crucial for function. For example, anti-apoptotic Bcl-2 family proteins prevent death signaling by heterodimerizing with pro-death proteins at their BH3 domains. ABT-263 is a potent, orally bioavailable mimetic of BH3 domains that avidly binds Bcl-2, Bcl-XL, and Bcl-W (Ki < 1 nM for all three proteins). It blocks the interaction of these proteins with pro-death proteins, like Bim, leading to apoptosis. ABT-263, alone, can induce regression of some tumors in some xenograft mouse models of cancer. It can also potentiate the therapeutic efficacy of chemotherapeutic compounds. Interestingly, ABT-263 induces apoptosis in cancer cell lines expressing mutants of β-catenin a Wnt signaling factor commonly mutated in a range of cancer types. |
| Product No. |
KT00025 |
| Product Name |
ABT263 |
| Synonyms |
A-855071 |
| Formal Name |
4-[4-[[2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-benzamide |
| CAS Number |
923564-51-6 |
| Molecular Formula |
C47H55ClF3N5O6S3 |
| Formula Weight |
974.6 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
1 year |
| Storage |
-20℃ |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500. |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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