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Sorafenib 
4-​[4-​[[[[4-​chloro-​3-​(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-​N-​methyl-​2-​pyridinecarboxamide
(CAS 284461-73-0)
Description:

The Raf kinases activate cellular pathways that lead to cell proliferation and can contribute to certain types of cancer. BAY-43-9006 is an inhibitor of Raf-1 and B-Raf (IC50 = 6 and 22 nM, respectively), as well as several receptor tyrosine kinases, including vascular endothelial growth factor receptors 2 and 3, platelet-derived growth factor receptor β, Flt-3, and c-KIT (IC50 = 90, 15, 20, 57, and 58 nM, respectively). It poorly inhibits ERK-1, MEK-1, and several other kinases (IC50 >10 μM). Through these effects BAY-43-9006 inhibits tumor angiogenesis and induces tumor cell apoptosis, particularly in renal cell carcinoma and hepatocellular carcinoma.

 

Product No. KT20010 
Product Name Sorafenib 
Synonyms Nexavar; Bay 43-9006
Formal Name 4-​[4-​[[[[4-​chloro-​3-​(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-​N-​methyl-​2-​pyridinecarboxamide
CAS Number 284461-73-0
Molecular Formula C21H16ClF3N4O3
Formula Weight 464.8
Formulation A crystalline solid
Purity 98%min
Stability 1 year
Storage -20°C
Shipping USD45 for Europe and USA. No shipping charge once amount reach USD500.
Quality Control HNMR,CNMR,LCMS,HPLC,IR,etc.
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