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AT7867 
4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine
(CAS 857531-00-1)
Description:

AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively; little activity outside the AGC kinase family.

in vivo: AT7867 shows bioavailability of 44% in mice by p.o. route. AT7867 could increase the cleaved PARP in MES-SA xenografts at 20 mg/kg i.p. or 90 mg/kg p.o.. AT7867 significantly inhibits the tumor growth in MES-SA xenografts or U87MG xenografts with T/C of 0.37 and 0.51, respectively.

 

Product No. KT00112 
Product Name AT7867 
Synonyms AT-7867;AT 7867
Formal Name 4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine
CAS Number 857531-00-1
Molecular Formula C20H20ClN3
Formula Weight 337.85
Formulation A crystalline solid
Purity 98%min
Stability 2 years
Storage -20°C
Shipping USD45 for Europe and USA. No shipping charge once amount reach USD500
Quality Control HNMR,CNMR,LCMS,HPLC,IR,etc.
Price & Availability In Stock. Price Negotiated.
 
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