| CPI-203 |
| (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide |
| (CAS 1446144-04-2) |
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| Description： |
CPI 203 is a novel potent, selective and cell permeable inhibitor of the bromodomain and extra terminal (BET) family protein BRD4 with an IC50 of ~37 nM (BRD4 α-screen assay).
Like JQ1, CPI203 inhibits BRD4 in vitro and in cells . CPI203 did not affect BRD4 kinase activity in vitro. In contrast, in vivo, specific Ser2 phosphorylation by either endogenous BRD4 or exogenous BRD4 FEE-AAA was markedly decreased by treatment with the inhibitor. |
| Product No. |
KT01026 |
| Product Name |
CPI-203 |
| Synonyms |
CPI203; CPI 203 |
| Formal Name |
(6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide |
| CAS Number |
1446144-04-2 |
| Molecular Formula |
C19H18ClN5OS |
| Formula Weight |
399.90 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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