| OTX-015 |
| (6S)-4-(4-chlorophenyl)-N-(4-hydroxyphenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide |
| (CAS 202590-98-5) |
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| Description： |
OTX-015 is a new potent BRD2/3/4 inhibitor with evident anti-proliferative activity in several cell lines representative of mature B-cell tumors.
OTX-015 demonstrated anti-proliferative activity in DLBCL cell lines (median IC50 0.192 uM). Similar results were obtained on SMZL (median IC50 0.165 uM), and on MM cell lines (median IC50 0.449 uM). MCL cell lines appeared less sensitive to OTX-015 (median IC50 2.01 uM). Among DLBCL cell lines, there was no difference based upon the cell of origin of the cell lines. OTX-105 caused a cell cycle arrest in G1 in a dose-dependent manner in 5/5 DLBCL and 3/3 MM cell lines, without an increase in cell death. |
| Product No. |
KT00627 |
| Product Name |
OTX-015 |
| Synonyms |
OTX 015; OTX015 |
| Formal Name |
(6S)-4-(4-chlorophenyl)-N-(4-hydroxyphenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide |
| CAS Number |
202590-98-5 |
| Molecular Formula |
C25H22ClN5O2S |
| Formula Weight |
491.99 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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