| TG100-115 |
| 3,3’-(2,4-Diamino-6,7-pteridinediyl)bisphenol |
| (CAS 677297-51-7) |
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| Description： |
TG100-115 is a PI3Kγ/δ inhibitor with IC50 of 83 nM/235 nM, with little effect on PI3Kα/β.
In human umbilical vein endothelial cells (HUVECs), TG100-115 (up to 10 μM) has no effects on cell proliferation and VEGF-stimulated ERK phosphorylation. However, TG100-115 (10 μM) interrupts other VEGF signaling pathways, such as those that culminate in VE-cadherin phosphorylation. [1] In HUVECs, TG100-115 (10 μM) inhibits the VEGF-induced increase of total level of VE-cadherin. TG100-115 inhibits VEGF mediated phosphorylation of mTOR and p70S6 kinase, both of which are downstream of PI3K. TG100-115 (125 nM to 10 μM) also inhibits FGF-stimulated phosphorylation of Akt.
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| Product No. |
KT00897 |
| Product Name |
TG100-115 |
| Synonyms |
TG100115; TG100 115 |
| Formal Name |
3,3’-(2,4-Diamino-6,7-pteridinediyl)bisphenol |
| CAS Number |
677297-51-7 |
| Molecular Formula |
C18H14N6O2 |
| Formula Weight |
346.30 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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