| Agomelatine |
| N-[2-(7-methoxy-1-naphthalenyl)ethyl]-acetamide |
| (CAS 138112-76-2) |
 |
| Description： |
Agomelatine is a competitive antagonist of human and porcine serotonin (5-HT2C) receptors (pKi = 6.2 and 6.4, respectively) as well as human 5-HT2B receptors (pKi = 6.6).
IC50 value: 6.2 (pKi, 5-HT2c); 6.6 (pKi, 5-HT2b)
Target: 5-HT2C Receptor; 5-HT2B receptor
It is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor. Activation of 5-HT2C receptors by serotonin inhibits dopamine and norepinephrine release. Antagonism of 5-HT2C results in an enhancement of DA and NE release and activity of frontocortical dopaminergic and adrenergic pathways. Agomelatine is also a potent agonist at melatonin receptors which makes it the first melatonergic antidepressant. Agomelatine is an antidepressant drug.
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| Product No. |
KT20190 |
| Product Name |
Agomelatine |
| Synonyms |
Valdoxan |
| Formal Name |
N-[2-(7-methoxy-1-naphthalenyl)ethyl]-acetamide |
| CAS Number |
138112-76-2 |
| Molecular Formula |
C15H17NO2 |
| Formula Weight |
243.3 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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