| Torin 2 |
| 9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]benzo[h]-1,6-naphthyridin-2(1H)-one |
| (CAS 1223001-51-1) |
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| Description： |
Torin 2 is a potent and selective mTOR inhibitor with IC50 of 0.25 nM; 800-fold greater selectivity for mTOR than PI3K and improved pharmacokinetic properties. Inhibition of ATM/ATR/DNA-PK with EC50 of 28 nM/35 nM/118 nM, respectively.
Torin 2 is a potent and selective inhibitor of cellular mTOR activity (EC50 = 0.3 nM).It shows more than 800-fold selectivity for mTOR over PI3K (EC50 = 200 nM) and greater than 100-fold binding selectivity relative to 440 other protein kinases.Torin 2 has significantly improved bioavailability (54%), metabolic stability, and plasma exposure compared to Torin 1.
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| Product No. |
KT00909 |
| Product Name |
Torin 2 |
| Synonyms |
Torin2; Torin-2 |
| Formal Name |
9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]benzo[h]-1,6-naphthyridin-2(1H)-one |
| CAS Number |
1223001-51-1 |
| Molecular Formula |
C24H15F3N4O |
| Formula Weight |
432.40 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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