| GDC-0449 |
| 2-chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-4-(methylsulfonyl)-benzamide |
| (CAS 879085-55-9) |
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| Description： |
Smoothened (SMO) is a cell surface receptor that, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. GDC 0449 is a potent antagonist of SMO that acts in a biphasic manner, with apparent high affinity (Ki = 1.3 nM) and low affinity (Ki = 2.3 µM) binding. It suppresses Gli-mediated transcription in CALU-6 tumors with an IC50 value of 13 nM and prevents hedgehog-dependent medulloblastoma allograft growth in mice. GDC 0449 less potently inhibits the ATP-binding cassette (ABC) proteins ABCG2 and ABCB1 (IC50 = 1.4 and 3.0 µM, respectively), which may ameliorate drug resistance. This compound has potential applications in several forms of cancer, including basal cell carcinoma.
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| Product No. |
KT00368 |
| Product Name |
GDC-0449 |
| Synonyms |
Vismodegib |
| Formal Name |
2-chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-4-(methylsulfonyl)-benzamide |
| CAS Number |
879085-55-9 |
| Molecular Formula |
C19H14Cl2N2O3S |
| Formula Weight |
421.3 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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