| FTY720 |
| 2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol, hydrochloride |
| (CAS 162359-56-0) |
 |
| Description： |
FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5). Down-regulation of S1P1 receptors on T and B lymphocytes by FTY720 results in defective egress of these cells from spleen, lymph nodes, and Peyer’s patch. FTY720 also enhances the activity of the sphingosine transporter Abcb1 and the leukotriene C4 transporter Abcc1 and inhibits cytosolic phospholipase A2 activity.
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| Product No. |
KT00362 |
| Product Name |
FTY720 |
| Synonyms |
FTY720 (hydrochloride),Fingolimod (hydrochloride) |
| Formal Name |
2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol, hydrochloride |
| CAS Number |
162359-56-0 |
| Molecular Formula |
C19H33NO2·HCl |
| Formula Weight |
343.9 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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| Related Products： |
azido-FTY720
Fingolimod
FK-506
FTY720 Phosphate
Fumonisin B1
Myriocin
S1P1 Polyclonal Antibody
S1P3 Polyclonal Antibody
SEW2871
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