| Fexofenadine hydrochloride |
|
| (CAS 153439-40-8) |
 |
| Description： |
Fexofenadine inhibits histamine H1 receptor with IC50 of 246 nM.
Fexofenadine exhibits a potent and concentration-dependent anti-anaphylactic activity with an IC50 value of 95.5nM. Fexofenadine shows only a weak competitive antagonist behaviour for the 5-HT2A receptorsfrom rat caudal artery with pA2 of 5.2. [1] All four P-gp inhibitors has a strong, concentration-dependent effect on the Papp of fexofenadine in both directions in the Caco-2 cell model. The IC50 of verapamil is 8.44 mM on the P-gp-mediated secretion of Fexofenadine.Fexofenadine causes a significant increase in the QT and Tp-e intervals and receives a significant TdP score at doses greater than 100 fold its free TPC in the rabbit left ventricular wedge preparation. |
| Product No. |
KT00356 |
| Product Name |
Fexofenadine hydrochloride |
| Synonyms |
CHEM-1861 |
| Formal Name |
|
| CAS Number |
153439-40-8 |
| Molecular Formula |
C32H40ClNO4 |
| Formula Weight |
538.12 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
|
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