| EX527 |
|
| (CAS 49843-98-3) |
 |
| Description： |
Mammalian sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent histone deacetylase (HDAC) with roles in energy metabolism and inflammation. EX-527 is a cell-permeable, selective inhibitor of SIRT1 (IC50 = 98 nM). It inhibits other SIRTs only at much higher concentrations and has no effect on other HDACs. EX-527 has been used to investigate the relationship between SIRT1-mediated deacetylation of p53, p53 activity, and cell survival following DNA damage. |
| Product No. |
KT00353 |
| Product Name |
EX527 |
| Synonyms |
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| Formal Name |
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| CAS Number |
49843-98-3 |
| Molecular Formula |
C13H13ClN2O |
| Formula Weight |
248.71 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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