| UK-5099 |
| 2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid |
| (CAS 56396-35-1) |
 |
| Description： |
UK-5099 is a potent inhibitor of plasma membrane monocarboxylate transporters (MCTs) and the mitochondrial pyruvate carrier (MPC); inhibits pyruvate-dependent O2 consumption with an IC50 of 50 nM.
The trypanosomal pyruvate carrier was found to be rather insensitive to inhibition by alpha-cyano-4-hydroxycinnamate (Ki = 17 mM) but could be completely blocked by UK5099 (Ki = 49 microM). Inhibition of pyruvate transport resulted in the retention, and concomitant accumulation, of pyruvate within the trypanosomes, causing acidification of the cytosol and osmotic destabilization of the cells. UK-5099 is more powerful inhibitor than alpha-cyano-4-hydroxycinnamate showing 50% inhibition of pyruvate-dependent O2 consumption by rat heart mitochondria at concentrations of 200, 200 and 50 nM respectively.
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| Product No. |
KT00936 |
| Product Name |
UK-5099 |
| Synonyms |
PF-1005023; UK5099; UK 5099; PF1005023; PF 1005023 |
| Formal Name |
2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid |
| CAS Number |
56396-35-1 |
| Molecular Formula |
C18H12N2O2 |
| Formula Weight |
288.30 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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