| UPF 1069 |
| 5-(2-Oxo-2-phenylethoxy)-1(2H)-isoquinolinone |
| (CAS 1048371-03-4) |
 |
| Description： |
UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM. It is ~27-fold selective against PARP1.
In vitro:UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM while inhibiting PARP1 with IC50 of 8 μM.
In vivo:In organotypic hippocampal slices, PARP-2 inhibition with UPF-1069 (0.01-1 mM) causes a concentration-dependent exacerbation (up to 155%) of oxygen-glucose deprivation (OGD)-induced CA1 pyramidal cell death. Higher concentrations, acting on both PARP-1 and PARP-2, have no effect on OGD injury. In mouse mixed cortical cells exposed to OGD, UPF-1069 (1-10 mM) significantly reduces post-ischaemic damage.
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| Product No. |
KT00940 |
| Product Name |
UPF 1069 |
| Synonyms |
UPF-1069; UPF1069 |
| Formal Name |
5-(2-Oxo-2-phenylethoxy)-1(2H)-isoquinolinone |
| CAS Number |
1048371-03-4 |
| Molecular Formula |
C17H13NO3 |
| Formula Weight |
279.29 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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