| DBEQ |
| N2,N4-bis(phenylmethyl)-2,4-quinazolinediamine |
| (CAS 177355-84-9) |
 |
| Description： |
The ATPase p97 is an ubiquitin-selective chaperone known to play a critical role in the degradation of misfolded membrane and secretory proteins and has been linked to various cellular processes that require unfolding and disassembly of protein complexes. DBeQ is a selective, reversible, and ATP-competitive inhibitor of the ATPase p97 (Ki = 3.2 μM; IC50 = 1.5 μM). It does not exhibit activity when tested against a panel 170 protein kinases at concentrations as high as 15 μM. At 10 μM it blocks endoplasmic reticulum-associated degradation, impairing the autophagy pathway and promoting the activation of caspase-3 and -7 in cancer cells.
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| Product No. |
KT00329 |
| Product Name |
DBEQ |
| Synonyms |
N,N’-Dibenzylquinazoline-2,4-diamine JRF 12 |
| Formal Name |
N2,N4-bis(phenylmethyl)-2,4-quinazolinediamine |
| CAS Number |
177355-84-9 |
| Molecular Formula |
C22H20N4 |
| Formula Weight |
340.4 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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