| CX5461 |
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| (CAS 1138549-36-6) |
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| Description： |
CX-5461 is a potent small-molecule rRNA synthesis inhibitor with an IC50 of 0.11M. Deregulated ribosomal RNA synthesis is associated with uncontrolled cancer cell proliferation. RNA Polymerase I (Pol I), the multi-protein complex that synthesizes rRNA, is activated widely in cancer. Thus, selective inhibitors of RNA PolI may offer a general therapeutic strategy to block cancer cell proliferation. CX-5461 selectively blocks RNA PolI transcription,PIC assembly and SL1-rDNA interaction. CX-5461 indicates potent antiproliferative activity in cancer cells and induces autophagy incancer cells. CX-5461 shows potent antitumor activity in A375 and MiaPaca xenografts.
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| Product No. |
KT00318 |
| Product Name |
CX5461 |
| Synonyms |
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| Formal Name |
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| CAS Number |
1138549-36-6 |
| Molecular Formula |
C27H27N7O2S |
| Formula Weight |
513.61 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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