CP 673451 is a selective inhibitor of PDGFRα/β with IC50 of 10 nM/1 nM, exhibits >450-fold selectivity over other angiogenic receptors, has antiangiogenic and antitumor activity.

in vivo: CP 673451 (once-daily p.o. ?0 days dosing routinely) inhibits tumor growth (ED50 < 33 mg/kg) in a number of human tumor xenografts grown s.c. in athymic mice, including H460 human lung carcinoma, Colo205 and LS174T human colon carcinomas, and U87MG human glioblastoma multiforme [1]. In RUCH2 xenograft-bearing mice, CP 673451 reduces tumor growth and stromal cell infiltration [2].

AC710

Amuvatinib

AZD2932

BIBF 1120

Crenolanib

DCC-2618

Pazopanib

PP121

SKLB610

SU14813

TAK-593