| CP-529 |
| 4S-[[[3,5-bis(trifluoromethyl)phenyl]methyl](methoxycarbonyl)amino]-2R-ethyl-3,4-dihydro-6-(trifluoromethyl)-1(2H)-quinolinecarboxylic acid, ethyl ester |
| (CAS 262352-17-0) |
 |
| Description： |
Cholesteryl ester transfer protein (CETP) catalyzes the exchange of cholesteryl esters from high-density lipoprotein (HDL) cholesterol to apolipoprotein B-containing lipoproteins, including very low-density lipoprotein (VLDL) and LDL. Torcetrapib is an inhibitor of CETP activity (IC50 = 50 nM) that raises HDL cholesterol and reduces LDL cholesterol levels by forming a nonproductive complex between CETP and HDL. Although torcetrapib produced consistent antiatherogenic effects in rabbits, clinical trials of torcetrapib were terminated early due to deleterious hypertensive effects. PDGFR, HGFR (c-Met), IL-2 receptor, and ErbB1- tyrosine kinase have subsequently been identified as direct off-targets of this compound. |
| Product No. |
KT00294 |
| Product Name |
CP-529 |
| Synonyms |
Torcetrapib |
| Formal Name |
4S-[[[3,5-bis(trifluoromethyl)phenyl]methyl](methoxycarbonyl)amino]-2R-ethyl-3,4-dihydro-6-(trifluoromethyl)-1(2H)-quinolinecarboxylic acid, ethyl ester |
| CAS Number |
262352-17-0 |
| Molecular Formula |
C26H25F9N2O4 |
| Formula Weight |
600.5 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
|
| Related Products： |
Dalcetrapib
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KU-60019
KU-55933
CGK733
TTP 22
TH-302 |
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