| Alvespimycin |
| 17-demethoxy-17-[[2-(dimethylamino)ethyl]amino]-geldanamycin |
| (CAS 467214-20-6) |
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| Description： |
Geldanamycin (Item No. 13355) is a potent inhibitor of Hsp90 that has poor water solubility. 17-DMAG is a water-soluble derivative of geldanamycin which potently inhibits Hsp90 (IC50 = 24 nM) and has excellent bioavailability and tissue distribution in animals. Like other Hsp90 inhibitors, 17-DMAG has diverse anti-tumor actions and has potential in treating certain types of cancer.This compound also suppresses inflammation by interfering with signaling through the NF-κB pathway.17-DMAG also ameliorates high fat diet-induced renal failure in a mouse model of diabetes.
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| Product No. |
KT20134 |
| Product Name |
Alvespimycin |
| Synonyms |
NSC 707545; 17-DMAG; KOS-1022 |
| Formal Name |
17-demethoxy-17-[[2-(dimethylamino)ethyl]amino]-geldanamycin |
| CAS Number |
467214-20-6 |
| Molecular Formula |
C32H48N4O8 |
| Formula Weight |
616.8 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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