| Teriflunomide |
| 2-Cyano-3-hydroxy-N-(4-trifluoromethylphenyl)crotonamide |
| (CAS 108605-62-5) |
 |
| Description： |
Teriflunomide is the active metabolite of leflunomide, inhibiting pyrimidine de novo synthesis by blocking the enzyme dihydroorotate dehydrogenase, used as an immunomodulatory agent.
Teriflunomide primarily acts as an inhibitor of dihydroorotate dehydrogenase (DHODH), a key mitochondrial enzyme involved in the de novo synthesis of pyrimidines in rapidly proliferating cells. By reducing the activity of high-avidity proliferating T lymphocytes and B lymphocytes, teriflunomide likely attenuates the inflammatory response to autoantigens in MS. Thus, teriflunomide can be considered a cytostatic rather than a cytotoxic drug to leukocytes.
|
| Product No. |
KT00951 |
| Product Name |
Teriflunomide |
| Synonyms |
2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide |
| Formal Name |
2-Cyano-3-hydroxy-N-(4-trifluoromethylphenyl)crotonamide |
| CAS Number |
108605-62-5 |
| Molecular Formula |
C12H9F3N2O2 |
| Formula Weight |
270.21 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
|
| Related Products： |
(S)-crizotinib
PTC-209
AZ191
CX-4945 (Silmitasertib)
Tacrolimus (FK506)
Verteporfin
|
|
