| Cladribine |
| 2-chloro-2’-deoxy-adenosine |
| (CAS 4291-63-8) |
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| Description： |
Cladribine is an adenosine analog which shows selective cytotoxicity against both proliferating and non-dividing lymphocytes. Resistant to adenosine deaminase, cladribine is phosphorylated by deoxycytidine kinase, resulting in its intracellular accumulation and inhibition of ribonucleotide reductase. It inhibits lymphocyte growth with an IC50 value of 45 nM. The pharmacokinetics of clabridine in humans have been published. After only a single course of treatment, clabridine eradicates hairy cell leukemia. It has potential use in a variety of hematologic malignancies, but its use in treating multiple sclerosis is compromised by serious adverse events.
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| Product No. |
KT00280 |
| Product Name |
Cladribine |
| Synonyms |
Jk 6251,Biodribin,NSC 105014,RWJ 26251,Leustatin |
| Formal Name |
2-chloro-2’-deoxy-adenosine |
| CAS Number |
4291-63-8 |
| Molecular Formula |
C10H12ClN5O3 |
| Formula Weight |
285.7 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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