| CK 636 |
| N-[2-(2-methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide |
| (CAS 442632-72-6) |
 |
| Description： |
CK-636(CK-0944636) is a small molecule inhibitor of Arp2/3 complex; Inhibitor of actin polymerization; Cell permeable inhibitor of human (IC50=4μM), fission yeast (IC50=24μM) and bovine (IC50=32μM) Arp2/3 complex between Arp2 and Arp3. Inhibits actin polymerization (IC50=22μM).
CK-636 binds between Arp2 and Arp3, where it appears to block movement of Arp2 and Arp3 into their active conformation. CK-636 inserts into the hydrophobic core of Arp3 and alters its conformation. Both classes of compounds inhibit formation of actin filament comet tails by Listeria and podosomes by monocytes.
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| Product No. |
KT00279 |
| Product Name |
CK 636 |
| Synonyms |
|
| Formal Name |
N-[2-(2-methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide |
| CAS Number |
442632-72-6 |
| Molecular Formula |
C16H16N2OS |
| Formula Weight |
284.4 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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