| Tacrolimus |
| 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26aS-hexahydro-5S,19R-dihydroxy-3S-[(1E)-2-(4R-hydroxy-3R-methoxycyclohexyl)-1R-methylethenyl]-14S,16S-dimethoxy-4R,10,12S, |
| (CAS 104987-11-3) |
 |
| Description： |
FK-506 is a potent, clinically-useful immunosuppressant in the same molecular class as cyclosporin A and rapamycin. Its mechanism of action involves the formation of a high affinity complex (Ki = 0.2 nM) with FK-506 Binding Protein 12 (FKBP12). This complex then inhibits the activity of the calcium/calmodulin-dependent protein phosphatase, calcineurin, leading to disruption of T-cell activation.The physiological effects of FK-506 also include regulation of nitric oxide neurotoxicity, neurotransmitter release, and regulation of Ca2+ release via the ryanodine and inositol-(1,4,5)-trisphosphate (IP3) receptors.3↗ In the latter case, FKBP12 forms a tight complex with both ryanodine and IP3 receptors which can be disrupted by FK-506, thereby rendering the receptors “leaky” to Ca2+.
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| Product No. |
KT20131 |
| Product Name |
Tacrolimus |
| Synonyms |
FK-506; Fujimycin; FR900506; FK506; FK 506 |
| Formal Name |
5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26aS-hexahydro-5S,19R-dihydroxy-3S-[(1E)-2-(4R-hydroxy-3R-methoxycyclohexyl)-1R-methylethenyl]-14S,16S-dimethoxy-4R,10,12S, |
| CAS Number |
104987-11-3 |
| Molecular Formula |
C44H69NO12 |
| Formula Weight |
804.0 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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