| CC-401 |
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| (CAS 395104-30-0) |
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| Description： |
CC-401 is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity.
n vivo: In acute disease, CC-401 blocked JNK signaling and reduced proteinuria in the first 24 h. The transient neutrophil influx seen at 3 h of disease was not affected, however. Continued CC-401 treatment suppressed glomerular and tubulointerstitial damage usually seen at 14 days [2]. Administration of CC-401 to rats prior to bilateral renal I/R prevented acute renal failure and largely prevented tubular damage, leucocyte infiltration and upregulation of pro-inflammatory molecules. However, delaying CC-401 treatment until 1 h after reperfusion (after the peak of JNK activation) had no protective effect [3].
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| Product No. |
KT00246 |
| Product Name |
CC-401 |
| Synonyms |
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| Formal Name |
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| CAS Number |
395104-30-0 |
| Molecular Formula |
C22H24N6O |
| Formula Weight |
388.47 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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| Related Products： |
AS 602801
CC-401 hydrochloride
CC-930
DB07268
JNK-IN-7
JNK-IN-8
SP600125
TCS JNK 5a
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