| VX702 |
| 6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide |
| (CAS 745833-23-2 (479543-46-9)) |
 |
| Description： |
VX-702 is a highly selective inhibitor of p38α MAPK, 14-fold higher potency against the p38α versus p38β.
Pre-incubation of platelets with VX-702 (1 μM) completely or partially inhibits p38 activation (IC50 4 to 20 nM) induced by platelet agonists including thrombin, SFLLRN, AYPGKF, U46619 and collagen. VX-702 shows no effect on platelet aggregation induced by any of the p38 MAPK agonists in the presence or absence of anti-platelet therapies. VX-702 inhibits the production of IL-6, IL-1β and TNFα (IC50 = 59, 122 and 99 ng/mL, respectively) in a dose-dependent manner.
|
| Product No. |
KT00964 |
| Product Name |
VX702 |
| Synonyms |
VX-702;VX 702 |
| Formal Name |
6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide |
| CAS Number |
745833-23-2 (479543-46-9) |
| Molecular Formula |
C19H12F4N4O2 |
| Formula Weight |
404.32 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
|
| Related Products： |
Skepinone-L
Losmapimod (GW856553X)
Sorafenib
SB203580
SB202190 (FHPI)
BIRB 796 (Doramapimod)
LY2228820
|
|
