Micafungin(FK463) is an echinocandin antifungal drug, Micafungin inhibits the production of beta-1,3-glucan, an essential component of fungal cell walls.
IC50 Value: > 100 ug/ml (ATCC 90028)
Target: antifungal; 1,3-beta-D-glucan synthase
in vitro: MCFG is also not active against deoxyribonucleic acid, ribonucleic acid or protein synthesis in C. albicans ATCC 90028 (IC50 s were both over 100 .MU.g/mL) . The effect of an optimal therapeutic dose of 10mg/ml-1 micafungin on the production of biofilm was monitored in vitro using a microtiter plate assay. For all the genes tested, the levels of mRNA transcription were also decreased significantly (p<0.05) in micafungin-treated samples cf. their untreated counterparts.
in vivo: In a mouse model of septic A. fumigatus infection, although non-treated mice survived for a maximum of only 6 days, the survival rate of micafungin-treated mice (0.1mg/kg-1) increased to 20%, while the survival rate of mice treated with a combination of micafungin (0.1mg/kg-1) and KB425796-C (32mg/kg-1) increased to 100% during the 31-day post-infection period .
Clinical trial: Pharmacokinetics of Micafungin in Critically Ill Patients. Phase not specified.

Anidulafungin
Ascomycin
Ketoconazole
Amphotericin B
Micafugin
Miconazole
Posaconazole
Sertaconazole
Terbinafine
Tioconazole
Voriconazole