| Tandutinib |
| 4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-methylethoxy)phenyl]-1-piperazinecarboxamide |
| (CAS 387867-13-2) |
 |
| Description： |
Tandutinib is a potent antagonist of platelet-derived growth factor receptor β (PDGFR-β), Flt3, and c-Kit (IC50 = 200, 220, and 170 nM, respectively). It less potently inhibits macrophage colony-stimulating factor 1 receptor (IC50 = 3.4 µM) and does not significantly inhibit other tyrosine or serine/threonine kinases. Tandutinib blocks the growth of cells expressing an internal tandem duplication within the juxtamembrane domain of the Flt3 receptor, found in some acute myelogenous leukemia cells. It also impairs the growth of colon cancer cells through its actions on the c-Kit receptor. Tandutinib reverses multidrug resistance in vitro by impairing the efflux activity of the multidrug resistance protein 7.
|
| Product No. |
KT20017 |
| Product Name |
Tandutinib |
| Synonyms |
MLN518; CT53518; MLN 518; CT 53518; MLN-518; CT-53518 |
| Formal Name |
4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-methylethoxy)phenyl]-1-piperazinecarboxamide |
| CAS Number |
387867-13-2 |
| Molecular Formula |
C31H42N6O4 |
| Formula Weight |
562.7 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
1 year |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500. |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
|
| Related Products： |
AGM925
Amuvatinib
AST487
ENMD-2076
ENMD-2076 Tartrate
BIBF 1120
PKC 412
BAY-43-9006
|
|
