| NSC 105823 |
| 5-amino-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamide |
| (CAS 2627-69-2) |
 |
| Description： |
AMP-activated protein kinase (AMPK) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress. AICAR is a selective activator of AMP-activated protein kinase (AMPK) in both hepatocytes and adipocytes. At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes. AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes. It also blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C/EBP pathways. |
| Product No. |
KT00033 |
| Product Name |
NSC 105823 |
| Synonyms |
AICA Riboside, Acadesine |
| Formal Name |
5-amino-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamide |
| CAS Number |
2627-69-2 |
| Molecular Formula |
C9H14N4O5 |
| Formula Weight |
258.2 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
1 year |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500. |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
|
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|
