ABT-888 |
|
(CAS 912444-00-9) |
|
Description: |
Biological Activity of ABT-888(Veliparib): ABT-888 is a potent inhibitor of both PARP-1 and PARP-2 by [3H]NAD+ with Kis of 5.2 and 2.9 nmol/L, respectively.The compound has good oral bioavailability and crosses the blood-brain barrier. ABT-888 strongly potentiated temozolomide in the B16F10 s.c. murine melanoma model. In the MX-1 breast xenograft model(BRCA1 deletion and BRCA2 mutation), ABT-888 potentiated cisplatin, carboplatin, and cyclophosphamide,causing regression of established tumors, whereas with comparable doses of cytotoxic agents alone, only modest tumor inhibition was exhibited |
Product No. |
KT00031 |
Product Name |
ABT-888 |
Synonyms |
Veliparib |
Formal Name |
|
CAS Number |
912444-00-9 |
Molecular Formula |
C13H16N4O |
Formula Weight |
244.29 |
Formulation |
|
Purity |
98%min |
Stability |
1 year |
Storage |
-20°C |
Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500. |
Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
Price & Availability |
In Stock. Price Negotiated. |
|
Related Products: |
A-966492
AG14361
AZD-2461
BMN-673
BMN-673 8R,9S
BSI-201
G007-LK
GW 501516 |
|