| ABT-888 |
|
| (CAS 912444-00-9) |
 |
| Description： |
Biological Activity of ABT-888(Veliparib): ABT-888 is a potent inhibitor of both PARP-1 and PARP-2 by [3H]NAD+ with Kis of 5.2 and 2.9 nmol/L, respectively.The compound has good oral bioavailability and crosses the blood-brain barrier. ABT-888 strongly potentiated temozolomide in the B16F10 s.c. murine melanoma model. In the MX-1 breast xenograft model(BRCA1 deletion and BRCA2 mutation), ABT-888 potentiated cisplatin, carboplatin, and cyclophosphamide,causing regression of established tumors, whereas with comparable doses of cytotoxic agents alone, only modest tumor inhibition was exhibited |
| Product No. |
KT00031 |
| Product Name |
ABT-888 |
| Synonyms |
Veliparib |
| Formal Name |
|
| CAS Number |
912444-00-9 |
| Molecular Formula |
C13H16N4O |
| Formula Weight |
244.29 |
| Formulation |
|
| Purity |
98%min |
| Stability |
1 year |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500. |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
|
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|
