| BMS-777607 |
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| (CAS 1025720-94-8) |
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| Description： |
BMS 777607 is a Small-Molecule Met Kinase Inhibitor with an IC50 of < 0.1M. Its treatment had little effect on tumor cell growth but inhibited cell scattering activated by exogenous HGF, with almost complete inhibition at 0.5mol/L in PC-3 and DU145 cells. This agent also suppressed HGF-stimulated cell migration and invasion in a dose-dependent fashion (IC50 < 0.1mol/L) in both cell lines. Mechanistically, nanomolar doses of BMS 777607 potently blocked HGF-stimulated c-Met autophosphorylation and downstream activation of Akt and extracellular signal-regulated kinase. In addition, both wortmannin and U0126, but not dasatinib, attenuated cell scattering and migration induced by HGF, suggesting the involvement of the phosphoinositide 3-kinase and mitogen-activated protein kinase pathways, but not of Src or focal adhesion kinase, in HGF-mediated motogenic effects.
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| Product No. |
KT00212 |
| Product Name |
BMS-777607 |
| Synonyms |
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| Formal Name |
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| CAS Number |
1025720-94-8 |
| Molecular Formula |
C25H19ClF2N4O4 |
| Formula Weight |
512.89 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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MK-8033
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