| BMS-599626 |
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| (CAS 8173837-23-1) |
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| Description： |
BMS-599626 is a highly selective pan-HERKinase inhibitor with IC50 of 20 and 30 nM for the inhibition of HER1and HER2, respectively. HER1 expression has been shown in as much as 80% to 90% of colon and non�Csmall- cell lung cancer. HER2 gene amplification and overexpression of the protein have been shown to occur in f30% of all breast cancer. BMS-599626 was highly selective when tested against a broad panel of diverse protein kinases. BMS-599626 abrogated HER1and HER2 signaling. BMS-599626 inhibited the proliferation of tumor cell lines that are dependent on these receptors, with IC50 in the range of 0.24 to1 ��M.
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| Product No. |
KT00205 |
| Product Name |
BMS-599626 |
| Synonyms |
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| Formal Name |
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| CAS Number |
8173837-23-1 |
| Molecular Formula |
C27H27FN8O3.HCl |
| Formula Weight |
567.01 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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