| WYE-687 |
| N-[4-[4-(4-Morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]carbamic acid methyl ester |
| (CAS 1062161-90-3) |
 |
| Description： |
WYE-687 is an ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM; blocks mTORC1/pS6K(T389) and mTORC2/P-AKT(S473) but no effect observed on P-AKT(T308). Selectivity for mTOR is greater than PI3Kα (>100-fold) and PI3Kγ (>500-fold).
WYE-687 is a potent ATP-competitive mTOR inhibitor with an IC50 of 7 nM. It is well reported that the mammalian target of rapamycin (mTOR) is centrally involved in cell growth, metabolism, and angiogenesis. Significantly, the pyrazolopyrimidines were selective for mTOR over PI3Kα (>100-fold) and PI3Kγ (>500-fold) and were poorly active in a panel of 24 protein kinases. Unlike the rapalogs, WYE-687 acutely blocked mTORC2-dependent phosphorylation of AKT in vitro and in vivo. In various cancer cells, WYE-687 inhibited the mTORC1 substrate P-S6K(T389) and mTORC2 substrate P-AKT(S473) at submicromolar concentrations without significant inhibition of P-AKT(T308). WYE-687 was identified as an ATP-competitive, and selective inhibitor of mTOR kinase activity.
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| Product No. |
KT00987 |
| Product Name |
WYE-687 |
| Synonyms |
WYE687;WYE 687 |
| Formal Name |
N-[4-[4-(4-Morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]carbamic acid methyl ester |
| CAS Number |
1062161-90-3 |
| Molecular Formula |
C28H32N8O3 |
| Formula Weight |
528.61 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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