| NVP-BKM120 |
| 5-(2,6-di-4-morpholinyl-4-pyrimidinyl)-4-(trifluoromethyl)-2-pyridinamine |
| (CAS 944396-07-0) |
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| Description： |
Phosphatidylinositol 3-kinases (PI3K) belong to a family of lipid kinases that is involved in many types of cancer. NVP-BKM120 is an orally bioavailable inhibitor of class I PI3K isoforms, potently blocking, in vitro, both p110α (IC50 = 52 nM) and p110β (IC50 = 166 nM). It much less effectively inhibits the class III PI3K Vps34 and mammalian target of rapamycin and has no effect on PI4Kβ and several other kinases. NVP-BKM120 prevents the growth of assorted cancer cell lines when used at 5 μM and inhibits tumor growth in vivo. It can be particularly effective against certain types of cancer when combined with other modulators.
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| Product No. |
KT00188 |
| Product Name |
NVP-BKM120 |
| Synonyms |
BKM120 |
| Formal Name |
5-(2,6-di-4-morpholinyl-4-pyrimidinyl)-4-(trifluoromethyl)-2-pyridinamine |
| CAS Number |
944396-07-0 |
| Molecular Formula |
C18H21F3N6O2 |
| Formula Weight |
410.4 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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