| BIX02189 |
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| (CAS 1094614-85-3) |
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| Description： |
BIX 02189 is a selective MEK5/ERK5 inhibitor with an IC50 of 59 nM. It inhibited catalytic function of purified, MEK5 enzyme. The MEK5 inhibitors blocked phosphorylation of ERK5, without affecting phosphorylation of ERK1/2 in sorbitol-stimulated HeLa cells. The compounds also inhibited transcriptional activation of MEF2C, a downstream substrate of the MEK5/ERK5 signaling cascade, in a cellular trans-reporter assay system.
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| Product No. |
KT00187 |
| Product Name |
BIX02189 |
| Synonyms |
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| Formal Name |
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| CAS Number |
1094614-85-3 |
| Molecular Formula |
C27H28N4O2 |
| Formula Weight |
440.54 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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