| BIBW2992 |
| N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide |
| (CAS 439081-18-2) |
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| Description： |
BIBW 2992 is an anilino-quinazoline that irreversibly inhibits EGFR and HER2 kinase activity in cell-free in vitro kinase assays (IC50s = 0.5 and 14 nM, respectively). It demonstrates potent activity against mutant forms of EGFR and HER2, including erlotinib-resistant isoforms (IC50 = 10 nM), and displays weak activity when evaluated against a panel of 52 additional tyrosine and serine/threonine kinases. BIBW 2992 suppresses transformation in isogenic cell-based assays, inhibits survival of cancer cell lines, and at 20 mg/kg, induces tumor regression in xenograft and transgenic lung cancer models.
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| Product No. |
KT00178 |
| Product Name |
BIBW2992 |
| Synonyms |
Tomtovok™,Afatinib |
| Formal Name |
N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide |
| CAS Number |
439081-18-2 |
| Molecular Formula |
C24H25ClFN5O3 |
| Formula Weight |
485.9 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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| Related Products： |
Canertinib (hydrochloride)
CUDC-101
Dovitinib
Lapatinib
Mubritinib
Pelitinib
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