| BAY-11-7085 |
| 3-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-2E-propenenitrile |
| (CAS 196309-76-9) |
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| Description： |
In the classical pathway of NF-κB activation, phosphorylation of the inhibitor of NF-κB (IκBα) releases the inhibitor from NF-κB, allowing IκBα degradation and NF-κB activation and nuclear import. BAY-11-7085 is an irreversible inhibitor of IκBα phosphorylation, preventing activation of NF-κB by cytokines and lipopolysaccharide (IC50 = 10 μM). It blocks gene expression that is regulated through the classical pathway of NF-κB activation and in this way blocks apoptosis, cell adhesion, and inflammation. BAY-11-7085 is also used to study IκBα actions that are independent of NF-κB signaling.
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| Product No. |
KT00156 |
| Product Name |
BAY-11-7085 |
| Synonyms |
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| Formal Name |
3-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-2E-propenenitrile |
| CAS Number |
196309-76-9 |
| Molecular Formula |
C13H15NO2S |
| Formula Weight |
249.3 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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BAY 11-7082
SC-514
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