| BEZ235 Tosylate |
|
| (CAS 1028385-32-1) |
 |
| Description： |
BEZ235 tosylate(NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM/5 nM/7 nM/75 nM/6 nM, respectively; inhibits ATR with IC50 of 21 nM; shown to be poor inhibitory to Akt and PDK1.
in vivo: BEZ235 induces regression of the tumors (69%) without statistically significant effect on body weight gain. Altogether, these preliminary in vivo efficacy results show that BEZ235 causes disease stasis when administered orally as a single agent and can enhance the efficacy of other anticancer agents when used in combination studies [1]. |
| Product No. |
KT00151 |
| Product Name |
BEZ235 Tosylate |
| Synonyms |
NVP-BEZ 235 Tosylate |
| Formal Name |
|
| CAS Number |
1028385-32-1 |
| Molecular Formula |
C37H31N5O4S |
| Formula Weight |
641.74 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
|
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|
