| Erlotinib |
| N-(3-ethylnylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine |
| (CAS 183321-74-6) |
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| Description： |
Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity (IC50 = 2.5 µM). This inhibits tumor growth in human head and neck carcinoma (HN5) tumor xenografts in mice with an ED50 value of 9 mg/kg. Erlotinib also suppresses cyclin-dependent kinase 2 (Cdk2) activity in breast cancer cells (IC50 = 4.6 µM) and JAK2 mutant JAK2V617F (IC50 = 5 µM), which is associated with polycythemia vera, idiopathic myelofibrosis, and essential thrombocythemia. The drug form of Erlotinib, Tarceva™, is used to treat certain forms of cancer, including non-small cell lung cancer.
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| Product No. |
KT20004 |
| Product Name |
Erlotinib |
| Synonyms |
NSC 718781; OSI-744; R-1415; OSI744; OSI 744; R1415; R 1415 |
| Formal Name |
N-(3-ethylnylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine |
| CAS Number |
183321-74-6 |
| Molecular Formula |
C22H23N3O4 |
| Formula Weight |
393.4 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
1 year |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500. |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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