| AZD2014 |
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| (CAS 1009298-59-2) |
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| Description： |
AZD2014 is a close analogue of AZD8055 and a selective inhibitor of mTOR kinase. AZD2014 has greater inhibitory activity against mTORC1 compared to rapamycin: AZD2014 decreases p4EBP1 Thr37/46, inhibits the translation initiation complex and decreases overall protein synthesis while rapamycin has no effect. AZD2014 also inhibits the mTORC2 biomarkers pAKTSer473 and pNDRG1Thr346. AZD2014 has broad antiproliferative activity across multiple tumour cell lines. In particular, AZD2014 induces growth inhibition and cell death in breast cancer cell lines, including ER+ cell lines with acquired resistance to hormone therapy.
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| Product No. |
KT00132 |
| Product Name |
AZD2014 |
| Synonyms |
AZD-2014 |
| Formal Name |
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| CAS Number |
1009298-59-2 |
| Molecular Formula |
C25H30N6O3 |
| Formula Weight |
462.54 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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| Related Products： |
AZD-8055
BEZ235
ETP-46464
GDC-0349
GDC-0980
GNE-477
GNE-493
GSK1059615
GSK2126458
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