| γ-Secretase Inhibitor XXI |
| N-[(1S)-2-[[(3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide |
| (CAS 209986-17-4) |
 |
| Description： |
γ-Secretase Inhibitor XXI, Compound E is a cell-permeable, potent, selective, peptidomimetic, non-transition-state analog inhibitor of γ-secretase and Notch processing (IC50 = 300 pM for Aβ40 in CHO cells overexpressing wild type βAPP.
240 pM for Aβ40, 370 pM for Aβ42, and 320 pM for NICD, respectively, in HEK293 cells stably transfected with βAPP695 and mNotchΔE(M1727V); 100 pM for both Aβ40 and Aβ42 in SH-SY5Y cells stably transfected with SPA4CT). γ-Secretase Inhibitor XXI, Compound E has been shown to lower Aβ levels in several APP transgenic mouse models. Also reported to bind to presenilins and suppress the proteolytic cleavage of transmembrane protein substrates, including APLP1 and APLP2, CD44, ErbB4, E-cadherin, low density lipoprotein receptor-related proteins, Notch ligands, and p75NTR. Weakly affects presenilinase activity at much higher concentrations (200-400 μM).
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| Product No. |
KT01022 |
| Product Name |
γ-Secretase Inhibitor XXI |
| Synonyms |
DuPont E;g-Secretase Inhibitor XXI |
| Formal Name |
N-[(1S)-2-[[(3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide |
| CAS Number |
209986-17-4 |
| Molecular Formula |
C27H24F2N4O3 |
| Formula Weight |
490.50 |
| Formulation |
|
| Purity |
98%min |
| Stability |
1 year |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500. |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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Compound E |
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