| Carvedilol |
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| (CAS 72956-09-3) |
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| Description： |
Carvedilol(BM14190) is a non-selective beta blocker/alpha-1 blocker with an IC50 of 3.8 μM for inhibition of LDL oxidation.
IC50 Value: 3.8 μM ( inhibition of LDL oxidation)
Target: beta Adrenergic Receptor
Carvedilol is a nonselective-blocking agent and is used in the treatment of hypertension and angina pectoris. As a third-generation β-adrenergic blocker (β-blocker), Carvedilol is able to reverse cardiac structural remodeling. Recentresults demonstrated that the effect caused by Carvedilol on cardiac remodeling is largely dependent on endogenous NO.
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| Product No. |
KT20795 |
| Product Name |
Carvedilol |
| Synonyms |
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| Formal Name |
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| CAS Number |
72956-09-3 |
| Molecular Formula |
C24H26N2O4 |
| Formula Weight |
406.47 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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| Related Products： |
(R)-(-)-Phenylephrine hydrochloride
(R)-(-)-Phenylephrine hydrochloride is a phenylephrine (PE) and an α1-adrenoceptor agonist
Target: α1- Adrenergic Receptor
Phenylephrine (PE), an alpha-adrenergic agonist and promoter of hypertrophic growth in the ventricular myocyte, to activate the three best-characterized mitogen-activated protein kinase (MAPK) subfamilies, namely p38-MAPKs, SAPKs/JNKs (i.e. stress-activated protein kinases/c-Jun N-terminal kinases) and ERKs (extracellularly responsive kinases), in perfused contracting rat hearts [1]. PE induced dose-dependent and fully reversible isometric contractions with a threshold concentration of 10 nM (n = 4), and an EC50 of 1 microM [2, 3].
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