| Fludarabine |
| 9-β-D-arabinofuranosyl-2-fluoro-9H-purin-6-amine |
| (CAS 21679-14-1) |
 |
| Description： |
Fludarabine(NSC 118218), a DNA synthesis inhibitor, is a chemotherapy drug used in the treatment of hematological malignancies.
Because of their antitumor activity via inhibition of DNA synthesis, purine nucleoside derivatives resistant to deamination have been developed for the treatment of various leukemias.Fludarabine is an adenosine deaminase resistant analog of 9-β-D-arabinofuranosyladenine (ara-A) that disrupts ribonucleotide reductase and DNA polymerase in blood cells. It exhibits antiproliferative activity (IC50 = 1.54 μM in an RPMI8226 myeloma cell line) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP, and survivin expression.Fludarabine is effective in a number of animal tumor systems including LI210 leukemia, CD8F mammary adenocarcinoma, P388 leukemia, and human LX-1 lung tumor xenograft and displays anticancer activity against human hematological malignancies in vivo
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| Product No. |
KT00598 |
| Product Name |
Fludarabine |
| Synonyms |
NSC 118218;F-ara-A |
| Formal Name |
9-β-D-arabinofuranosyl-2-fluoro-9H-purin-6-amine |
| CAS Number |
21679-14-1 |
| Molecular Formula |
C10H12FN5O4 |
| Formula Weight |
285.23 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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