| NU 6027 |
| 6-(cyclohexylmethoxy)-5-nitroso-2,4-pyrimidinediamine |
| (CAS 220036-08-8) |
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| Description： |
NU 6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurine-based inhibitors.
Cyclin-dependent kinases (CDKs) play a key role in regulating cell division by phosphorylating distinct substrates in different phases of the cell cycle. Cell cycle deregulation in many cancers often results from altered CDK activity. Thus, CDKs are potential pharmacological targets for anticancer agents. NU 6027 inhibits both CDK1 and CDK2 with IC50 values of 2.9 and 2.2 µM, respectively.It has been shown to inhibit cellular ataxia telangiectasia mutated and Rad3-realted kinase activity (IC50 = 6.7 µM) and impair G2/M arrest in various human cancer cells, potentiating the cytotoxic effects of DNA-damaging, anticancer agents such as cisplatin.
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| Product No. |
KT00611 |
| Product Name |
NU 6027 |
| Synonyms |
NU6027;NU-6027 |
| Formal Name |
6-(cyclohexylmethoxy)-5-nitroso-2,4-pyrimidinediamine |
| CAS Number |
220036-08-8 |
| Molecular Formula |
C11H17N5O2 |
| Formula Weight |
251.28 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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