| ONO-8711 |
| (5Z)-6-[(2R,3S)-3-[[[(4-Chloro-2-methylphenyl)sulfonyl]amino]methyl]bicyclo[2.2.2]oct-2-yl]-5-hexenoic acid |
| (CAS 216158-34-8) |
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| Description： |
Prostaglandin E2 (PGE2) initiates its cellular effects by activating one of four E prostanoid (EP) receptors, EP1-4. ONO-8711 is a potent and selective competitive antagonist of the EP1 receptor (Ki = 0.6 and 1.7 nM for human and mouse EP1, respectively, versus 67 and 76 nM for mouse EP3 and human thromboxane receptor, respectively, and >1,000 nM for other receptors).ONO-8711 effectively reduces tumor incidence and multiplicity in mouse models of colon, breast, and oral cancer.It also suppresses pain and acid-induced HCO3- secretion in the stomach.
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| Product No. |
KT00624 |
| Product Name |
ONO-8711 |
| Synonyms |
ONO8711;ONO 8711 |
| Formal Name |
(5Z)-6-[(2R,3S)-3-[[[(4-Chloro-2-methylphenyl)sulfonyl]amino]methyl]bicyclo[2.2.2]oct-2-yl]-5-hexenoic acid |
| CAS Number |
216158-34-8 |
| Molecular Formula |
C22H30ClNO4S |
| Formula Weight |
440.00 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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